Corteva has confirmed it will discontinue production of Enlist Duo, a herbicide containing a mix of 2,4-D (an active ingredient in Agent Orange) and glyphosate, following over a decade of litigation and public pressure. The decision removes a product linked to cancer and ecological damage from the U.S. market, where it was applied annually to 4.5 million acres of corn, soybeans, and genetically engineered cotton. For overseas chemical buyers, this signals a shift in Corteva's portfolio and potential supply gaps for 2,4-D/glyphosate combination herbicides.
Product discontinuation details
Corteva confirmed that Enlist Duo will no longer be produced, citing that it now represents only 1 percent of sales. The company stated this decision is part of a broader effort to streamline its portfolio and does not affect the production or availability of Enlist One, which remains a market-leading solution. Enlist One contains 2,4-D but not glyphosate.
Regulatory and legal context
The U.S. Environmental Protection Agency (EPA) had continued to approve Enlist Duo despite a decade of litigation and public pressure campaigns to ban its use. A lawsuit asking a judge to invalidate its approval is ongoing. Kristina Sinclair, a staff attorney with the Center for Food Safety (CFS), noted that after over a decade of legal battles, the manufacturer pulled the product rather than rebut arguments in court.
Health and environmental concerns
Enlist Duo contains 2,4-D, an active ingredient in Agent Orange, which the World Health Organization categorizes as a "possible" carcinogen linked to non-Hodgkin lymphoma, birth defects, respiratory problems, Parkinson's disease, and reproductive harms. Glyphosate has also prompted litigation over its cancer-causing properties. The Center for Food Safety wrote that the herbicide harms endangered species including butterflies, birds, fish, deer, panthers, and bats.
What buyers should watch
Overseas buyers sourcing herbicides should note that Corteva will continue to produce Enlist One, which uses 2,4-D alone. The discontinuation of Enlist Duo may affect supply chains for combination 2,4-D/glyphosate products. Regulatory scrutiny on 2,4-D and glyphosate remains high globally, and buyers should monitor ongoing litigation and potential EPA re-evaluations. Nathan Donley of the Center for Biological Diversity criticized the EPA's focus on getting pesticides to market, suggesting future regulatory shifts are possible.
Source: Read the original report | Published: February 17, 2026